Publications

研究成果

Key publications - Original papers 代表著作

C. Abrahamian, R. Tang, R. Deutsch, L. Ouologuem, J. Blenninger, E. Weiden, V. Kudrina, J. Rilling, C. Feldmann, Y. Stepanov, A. Scotto Rosato, G. Calvo, M. Soengas, T. Gudermann, M. Biel, C. Wahl-Schott, C.-C. Chen, K. Bartel, S. Kuss, D. Mayr, T. Frohlich, C. Grimm. Rab7a is an enhancer of TPC2 activity regulating melanoma progression through modulation of the GSK3β/β-Catenin/MITF-axis. Nature Communications (2024) 15:10008

K. Gibbs, L. Wang, Z. Yang, C. Anderson, J. Bourgeois, Y. Cao, M. Gaggioli, M. Biel, R. Puertollano, C.-C. Chen & D. Ko. Human variation impacting MCOLN2 restricts Salmonella Typhi replication by magnesium deprivation. Cell Genomics (2023) 3, 100290

B. Spix, E. Butz, C.-C. Chen, A. S. Rosato, R. Tang, A. Jeridi, V. Kudrina, E. Plesch, P. Wartenberg, E. Arlt, D. Briukhovetska, M. Ansari, G. G. Günsel, T. Conlon, A. Wyatt, S. Wetzel, D. Teupser, L. Holdt, F.n Ectors, I. Boekhoff, U. Boehm, J. García-Añoveros, P. Saftig, M. Giera, S. Kobold, H. Schiller, S. Zierler, T. Gudermann, C. Wahl-Schott, F. Bracher, A. Yildirim, M. Biel, C. Grimm. Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice. Nature communications (2022) 13, 318

C.-C. Chen*‡, E. Krogsaeter*, E. Butz, Y. Li, R. Puertollano, C. Wahl-Schott, M. Biel, C. Grimm. TRPML2 is an osmo-/ mechano-sensitive cation channel in endolysosomal organelles. Science Advances (2020) 6;eabb5064

S. Gerndt*, Y.-K. Chao*, C.-C. Chen*, Y. Yuan*, S. Burgstaller, A. S. Rosato, E. Krogsaeter, N. Urban, K. Jacob, O. N. P. Nguyen, M. Miller, M. Keller, A. Vollmar, T. Gudermann, J. Schredelseker, S. Zierler, E. Polishchuk, M. Schaefer, M. Biel, D. M‡edina, R. Malli, C. Wahl-Schott, F. Bracher, S. Patel, C. Grimm. Agonist-mediated switching of ion selectivity in two-pore channel 2 differentially promotes lysosomal function. EIife (2020) 9:e54712

E. Plesch*, C.-C. Chen*, E. Butz*, A. S. Rosato, E. Krogsaeter, H. Yinan, K. Bartel, M. Keller, D. Robaa , D. Teupser, L. Holdt, A. M. Vollmar, W. Sippl, R. Puertollano, D. L. Medina, M. Biel, C. Wahl-Schott, F. Bracher, C. Grimm. Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells. Elife (2018) 7, e39720

C.-C. Chen*, C. Cang*, S. Fenske, E. Butz, Y.-K. Chao, M. Biel, D. Ren, C. Wahl-Schott, C. Grimm. Patch clamp technique to characterize ion channels in enlarged individual endolysosomes. Nature Protocols (2017) 12:1639

C.-C. Chen*, E. Butz*, Y.-K. Chao, Y. Grishchuk, L. Becker, S. Heller, S. Slaugenhaupt, M. Biel, C. Wahl-Schott, C. Grimm. Small molecules for early endosome-specific patch clamping. Cell Chemical Biology (2017) 24; 7:907

Y. Sakurai, A. A. Kolokoltsov, C.-C. Chen, M. W. Tidwell, W. E. Bauta, N. Klugbauer, C. Grimm, C. Wahl-Schott, M. Biel, R. A. Davey. Two pore channels control Ebolavirus entry into host cells and are targets for disease treatment. Science (2015) 347;6225:995

* These authors contributed equally ‡ Corresponding author

S. Patel, Y. Yuan, C.-C. Chen, D. Jaślan, G. Gunaratne, C. Grimm, T. Rahman, J. Marchant. Electrophysiology of endolysosomal two-pore channels: A current account. Cells (2022) 11, 2368
C.-C. Chen‡, E. Krogsaeter, C.-Y. Kuo, M.-C. Huang, S.-Y. Chang, M. Biel. Endolysosomal cation channels point the way towards precision medicine of cancer and infectious diseases. Biomedicine & Pharmacotherapy (2022) 148. 112751

C.-C. Chen‡, E. Krogsaeter, C. Grimm. Two-pore and TRP cation channels in endolysosomal osmo-/mechanosensation and volume regulation. BBA - Molecular Cell Research (2020) 1868:118921

B. Spix*, Y.-K. Chao*, C. Abrahamian*, C.-C. Chen, C. Grimm. TRPML cation channels in inflammation and immunity. Frontiers in Immunology (2020) 11;225

C. Grimm, E. Butz, C.-C. Chen, C. Wahl-Schott, M. Biel. From mucolipidosis type IV to Ebola: TRPML and two-pore channels at the crossroads of endolysosomal trafficking and disease. Cell Calcium (2017) 17; 30046

C. Grimm, C.-C. Chen, C. Wahl-Schott, M. Biel. Two-Pore Channels: Catalyzers of endolysosomal transport and function. Front. Pharmacol. (2017) 8;45

C.-C. Chen‡. Electrophysiological Techniques on the Study of Endolysosomal Ion Channels. Endolysosomal Voltage-Dependent Cation Channels. Handbook of Experimental Pharmacology (Springer Nature, 2023) PMID: 36871125. ISBN: 978-3-031-31523-7

S. Rautenberg, M. Keller, C. Leser, C.-C. Chen, F. Bracher, Ch. Grimm. Expanding the toolbox: novel modulators of endolysosomal cation channels. Endolysosomal Voltage-Dependent Cation Channels. Handbook of Experimental Pharmacology. (Springer Nature, 2023) ISBN: 978-3-031-31523-7

C.-C. Chen‡, C. Grimm, C. Wahl-Schott, M. Biel. Endolysosomal patch-clamping: approaches to measure vesicular ion channel activities. Ion and Molecule Transport in Lysosomes. (CRC Press, 2020) B. Gasnier, M. Zhu, Eds. ISBN 9781138560390.

Exploring Endolysosomal Ion Channels: Significance and Methodologies, Bordeaux Neurocampus, France, 11.10.24 Host: Eric Boue-Grabot

Using novel endo-lysosomal patch-clamp to investigate the mechanism of TPC2 and TRPML2 in viral trafficking and its implication in the viral diseases, 2023 Biomedical Research Symposium of National Health Research Institutes, Taiwan, 10.08.23 Host: Rean Wu

TRPML2 sets codes for redistribution of apical endosomes, Walther-Straub-Institute for Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians University (LMU) Munich, Germany. 03.02.23 Host: Christian Grimm

TRPML2 activations determine intracellular vesicles specific distribution and functions, Institute of Cardiovascular Physiology and Pathophysiology, Biomedical Center of the LMU Medical Faculty, Munich, Germany. 26.01.23 Host: Christian Wahl-Schott

Endolysosomal ion channels point the way towards precision medicine, Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan. 12.12.22 Host: Wen-Chien Chou

The patch-clamp technique in endolysosomal ion channel research, Brain Research Center (BRC), NYMU, Taiwan, 16.04.21 Host: Yeh-Shiu Chu

Endo-lysosomal ion channels in health and disease, Institute of Anatomy and Cell Biology, National Taiwan University, Taiwan, 25.06.19 Host: Neng-Yu Lin

Characterization of TRPML2 in endolysosomes, Institute for Neurophysiology, Hannover Medical School, Germany, 22.05.19 Host: Christian Wahl-Schott

An electrophysiological approach to analyse TRPML2 in endolysosomes, Oxford talk, Department of Pharmacy, University of Oxford, 27.07.18 Host: Antony Galione

Characterization of TRPML2 on intracellular organelles from macrophages, 3rd European Calcium Channel Conference 2018 (ECCC), Alpbach, Austria, 9-12.05.18 Chair: Martin Biel

Endolysosomal ion channels: A new approach to treat NCL?, 3rd JNCL Young Investigator Symposium, NCL Foundation, Hamburg, Germany, 6-8.08.17

Instructor: Whole Endolysosomal Patch Clamp Technique to analyze TRPML1 channel, CAJAL Advanced Neuroscience Training Programme “Ion channels in the brain in health and disease”, Bordeaux School of Neuroscience, FENS France, 4-22.09.17

An electrophysiological approach to analyze organellar two-pore channels regulating Ebola virus infection, Institute of Biophotonics, National Yang-Ming University, Taiwan, 04.01.16 Host: Wolfgang Fischer

Two-Pore Channels and Tetrandrine Regulate Ebola Virus Infection, Gordon Research Conference “Organellar Channels & Transporters”, Waltham, USA, 14-19.06.15 Chair: Haoxing Xu