癌症、老化、神經退化、抗藥性及新興感染症是醫學上懸而未解的世紀難題。內溶酶體離子通道如何調控胞器運輸及影響細胞生理，是了解這些疾病分子病理機制的關鍵。本實驗室以內溶酶體電生理及鈣訊號影像分析技術為核心，與國內外研究機構合作，詳細探討細胞內胞器離子通道的功能與應用，並研發推廣下一代的高解析度內溶酶體電生理技術。

     Cancer, aging, neurodegeneration, and emerging viral infections are unsolved problems of the century in medicine. How endolysosome ion channels regulate organelle functions is the key to understand the pathogenesis of these diseases. With the cutting-edge endo-lysosomal electrophysiological technique and calcium imaging, our laboratory aims to investigate the electrophysiological properties of intracellular organelle ion channels and identify novel drug targets for therapeutic strategy precision medicine.

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