Endolysosomal Ion Channels & Diseases 2025
內溶小體離子通道與疾病國際研討會
OCT 25
National Taiwan University, College of Medicine
Sailing the Blue Ocean of Endolysosomal Ion Channels into a New Golden Age of Drug Discovery.
We are delighted to welcome you to the 2nd International Symposium on Endolysosomal Ion Channels and Diseases (ELiD 2025), to be held on October 25, 2025, at National Taiwan University College of Medicine, Taipei.
Following the resounding success of ELiD 2024—which gathered over 200 participants from eight countries across Asia, Europe, and North America—this year’s symposium continues our commitment to fostering global collaboration and driving scientific advancement in this rapidly evolving field.
The 2025 theme invites participants to explore the expanding blue ocean of endolysosomal ion channel research—an emerging frontier where fundamental science meets translational innovation. From unraveling ion channel mechanisms to understanding their roles in immunity, neurodegeneration, and rare genetic diseases, ELiD 2025 brings together world-leading scientists, rising stars, and industry pioneers to chart new directions in biomedical science and therapeutic discovery.
We look forward to welcoming you on board. Join us in Taipei as we set sail toward the next wave of breakthroughs.
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Welcome to ELiD 2025
Keynote Speakers
ION CHANNEL EXPERTS
Thomas Jentsch
Professor; FMP, MDC and Charité Berlin, Germany
德國萊布尼茲柏林分子藥理研究所暨柏林夏里特大學醫學院教授 德國國家院士
Prof. Jentsch is a pioneer in ion channel research, best known for discovering the first chloride channel gene (ClC-0) and defining the CLC family. He revealed that many CLC proteins are Cl⁻/H⁺ exchangers, transforming our understanding of membrane transport. His mouse models helped uncover the roles of CLCs in the brain, kidney, and muscle, and their links to diseases like epilepsy and deafness. Thomas Jentsch院士是國際離子通道研究的開創者，首度鑑定出氯離子通道基因 ClC-0，並逐步發現與闡明整個 CLC 家族成員的功能。他的研究顛覆傳統觀點，指出多數 CLC 蛋白兼具氯離子通道與氯氫交換子的雙重功能，重塑我們對膜運輸機制的理解。透過基因改造小鼠模型，他系統性揭示 CLC 家族在大腦、腎臟與肌肉中的生理角色，並說明其缺陷與癲癇、聽力障礙、腎病與骨硬化症等人類疾病的關聯。Jentsch教授獲獎無數，包括德國萊布尼茲獎、德國生理學會榮譽會員等，為當代生物醫學界極具影響力的科學家之一。
Christian Wahl-Schott
Professorship of Cardiovascular Physiology and Pathophysiology, LMU Munich, Germany 德國慕尼黑大學心血管生理與病理生理學研究所所長
Prof. Christian Wahl-Schott is Chair of Cardiovascular Physiology at LMU Munich. His research focuses on hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and their roles in cardiac rhythm and neuronal excitability. In parallel, he has contributed to studies of endolysosomal ion channels such as TPCs, revealing their impact on lipid metabolism and rare diseases. His work bridges membrane electrophysiology and organellar signaling. Wahl-Schott教授帶領的研究團隊長期致力於高表極化活化環核苷酸門控通道（HCN）在心律調控與神經興奮性中的角色研究。同時，他亦參與探討雙孔通道（TPC）等內溶小體離子通道對脂質代謝與罕病機制的影響，研究橫跨膜電生理與胞器訊號傳導。
Eric Boué-Grabot
Deputy Director, Neurodegenerative Disease Institute (IMN), University of Bordeaux. 法國國家科學研究中心主任暨波爾多大學神經退化疾病研究所副所長
Dr. Boué-Grabot has revealed novel molecular and functional roles of P2X channels in neuroinflammation, synaptic plasticity, and diseases such as ALS, pain, epilepsy, and psychiatric disorders. Combining electrophysiology, imaging, and behavioral studies in rodent models, his lab also develops transgenic mice to explore microglial versus neuronal receptor functions. Dr. Eric Boué-Grabot 為法國國家科學研究中心（CNRS）研究主任，現任波爾多大學神經退化疾病研究所副所長。他領導研究團隊探討腦中嘌呤受體（特別是 P2X 受體）於神經發炎與突觸可塑性的功能，並關注其在漸凍人症、疼痛、癲癇與精神疾病中的角色。研究方法結合電生理、影像與動物行為分析，並建立轉基因鼠模進一步釐清神經元與小膠質細胞中受體的分工。
Martin Biel
Chair of Pharmacology, LMU Munich, Germany. 德國慕尼黑大學藥理學教授
Prof. Biel has significantly advanced our understanding of ion channels, including HCN and TPC channels, in physiology and disease. He is a member of the German Academy of Sciences Leopoldina and co-founder of ViGeneron GmbH. His recent work also explores gene therapy strategies targeting the retina. Biel教授的研究專注於離子通道在神經系統與心血管系統中的功能與病理生理意義，特別是環核苷酸調控的離子通道（如 CNG 和 HCN 通道）以及內溶酶體離子通道（如 TPC 和 TRPML）。Biel 教授的實驗室運用多種方法，包括電生理學、分子生物學、生化技術和病毒基因轉移技術，並特別強調使用遺傳小鼠模型來研究離子通道的功能。他的研究與多種臨床相關的人類疾病有關，如心律不整、非酒精性脂肪肝炎、高脂蛋白血症、動脈粥樣硬化、癲癇和疼痛。此外，Biel 教授推動德國第一個進入臨床試驗階段的眼科基因治療計畫。他也是德國國家科學院 Leopoldina院士和巴伐利亞科學院副主席。
Dejian Ren
University of Pennsylvania, USA 賓州大學生物系研究所所長
Prof. Ren is Professor of Biology at the University of Pennsylvania. His pioneering work on ion channels in lysosomes and the nervous system has led to the discovery of multiple novel channels and mechanisms. He is recognized for landmark publications in Nature, Cell, and Science. He also developed patch-clamp techniques for intracellular organelles. 任教授現任賓州大學生物系教授，其研究開創性地揭示了溶酶體與神經系統中離子通道的新機制，發表多篇刊登於 Nature、Cell、Science 的經典論文。他同時開發內部胞器的膜片鉗技術，拓展胞器電生理研究的新領域。
Michael X. Zhu
University of Texas Health Science Center at Houston, USA 德州大學教授
Prof. Zhu discovered that TPCs act as NAADP-sensitive lysosomal calcium channels and established TRPML channels as key regulators of organelle function. He also edited several landmark books on TRP channel signaling and lysosomal ion transport. 朱曦教授是休士頓健康科學中心綜合生物與藥理學系教授，是細胞內離子通道研究的權威，特別聚焦於 TRPML 與 TPC 家族。他亦主編多部離子通道與溶酶體運輸的經典專書，對該領域具深遠影響。
The Venue
National Taiwan University College of Medicine. Basic Medical Science Building, Lecture Hall 101
台灣大學醫學院基礎醫學大樓 101講堂
National Taiwan University College of Medicine
Established in 1897, NTU College of Medicine is Taiwan’s leading institution for medical education, research, and clinical training. In close partnership with NTU Hospital, the College drives innovation in health sciences and fosters global collaboration to improve human health.
Program
09:00 OPENING REMARKS // Honorary Chair: SungLiang Yu (NTU)
09:10 Thomas Jentsch (FMP Berlin) // KEYNOTE SPEECH // Honorary Chair: Cheng-Chang Lien (NYCU)
TMEM9 proteins: New players in endosomal ion transport and neurological disorders
TRP Session // Chair: Chia-Lin Hsu (NYCU)
09:50 Cheng-Chang Chen (NTU) //
Targeting Endolysosomal Ion Channels by Electrophysiology: TRPML2 and Beyond
10:05 Pei-Shan Hou (NYCU) //
10:20 Tzu-Ming Jao (NTU) //
COFFEE BREAK
TPC Session // Chair: Ya-Wen Liu (NTU)
10:50 Neng-Yu Lin (NTU) //
11:05 Tai-Ling Chao (NTU) //
11:20 Takushi Shimomura (NIPS, Japan) // GUEST SPEECH // Chair: Mei-Ru Chen (NTU)
A switching role of the 2nd S4 helix in the voltage- and PIP2-dependence of Two-Pore channels revealed by voltage clamp fluorometry
Organelle Membrane Session
11:50 Ruey-Hwa Chen (Sinca) // GUEST SPEECH // Chair: Chi-Kuang Yao (Sinca)
Bro1 proteins control lysosome and exosome fates of multivesicular bodies for regulating tumor immunity and metastasis
12:20 LUNCH & POSTER SESSION
13:30 Christian Wahl-Schott (LMU Munich) // KEYNOTE SPEECH // Chair: Sui-Yuan Chang (NTU)
Selected Poster Oral Presentation // Chair: Ching-Ying Kuo (NTU) & Yu-Huan Tsai (CGU)
14:10 Markus Rapedius (Nanion)
14:25 Selected Poster Flash Talk 7 min + 3 min Q&A #1 #2 #3 #4
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15:05 Eric Boue-Grabot (CRNS) // KEYNOTE SPEECH // Chair: Ya-Chien Yang
P2X4 Receptors at the Cell Surface and in Endolysosomes: Roles in Brain Health and Disease
15:45 COFFEE BREAK & POSTER SESSION
Keynote Discussion // Honorary Chair: Michael X. Zhu (Texas)
16:30 Martin Biel (LMU Munich), Dejian Ren (UPenn), Thomas Jentsch (FMP Berlin) // PANEL DISCUSSION
17:10 CLOSING REMARKS // Honorary Chair: Michael X. Zhu (Texas)
Organizers
We are delighted to welcome you to ELiD 2025, held at National Taiwan University in Taipei from October 25, 2025. This international symposium brings together leading researchers in the fields of ion channel physiology, membrane trafficking, and lysosomal biology to explore the emerging roles of endolysosomal ion channels in health and disease.
Honorary Chair, Cheng-Chang Lien, NYCU
Honorary Chair, SungLiang Yu, NTU
Honorary Chair, Michael X. Zhu, Texas
Cheng-Chang Chen, NTU
國立臺灣大學醫學院醫學檢驗暨生物技術學系
臺大醫學檢驗暨生物技術學系系友會
臺灣基因體暨遺傳學會
國家科學及技術委員會
Our Sponsors
LEADING IN THE INDUSTRY
Join us in Taipei on October 25, 2025, for a high-impact symposium uniting experts in ion channels, lysosomal biology, and drug discovery.
Sponsorship offers visibility, networking, and outreach to top scientists and biotech innovators.
Flexible packages available—exhibition booths, logo display, and more.
Contact us: Dr. Cheng-Chang Chen chenchengchang@ntu.edu.tw
與 ELiD 2025 攜手合作，讓您的品牌站上國際舞台
ELiD 2025 是聚焦離子通道與藥物開發的國際研討會，匯集來自學術界與產業界的頂尖專家與新銳人才，為企業提供絕佳的曝光與合作契機。我們誠摯邀請您成為贊助夥伴，共同推動轉譯醫學發展。贊助方案彈性多元，包含展位展示、講者機會、品牌露出與產品示範。支持 ELiD 2025，不僅是投入學術交流與創新研發，更是與全球頂尖研究者同行的最佳時機。